Bioinformatics - answers

Exercise 1:

3·109 x 0,34·10-9 = 1 m

Exercise 2:

1 m x 75·1012 = 75·1012 m
= ten thousand times to the Moon and back again = 500 return trips to the Sun

Exercise 3:

You can calculate this in two ways, considering that there are 3 billion base PAIRS present in a cell. Strictly taken, you should write down 6 billion bases in the books. Nevertheless, calculating with only 3 billion bases is also correct since they are complementary to the other 3 billion. This calculation takes 6 billion bases into account:

For each book: 107 bases (1000 x 10000). So we need 600 books with a total height of 600 x 5 cm = 3000 cm = 30 m

Exercise 4:

You only need 2 DVDs and even less if you use some kind of data compression.

Exercise 5:

Exercise 6:

YearMilestoneType
1590Invention of the microscopeExperimental
1663First description of cellsDiscovery
1830First description of proteinsDiscovery
1833First purification of enzymesExp./Disc.
1906The word genetics makes its first appearance--
1919The concept of biotechnology is introduced--
1944Avery proves that DNA is the molecule containing genetic informationDiscovery
1946ENIAC, the first programmable computer able to perform 5000 calculations in one second, is builtComputer
1951Pauling and Corey describe α-helices and β-sheetsDiscovery
1953Watson and Crick describe the 3D structure of DNADiscovery
1958Development of the first microchipComputer
1970A method is developed to compare sequences (Needleman-Wunsch)Experimental
1971Ray Tomlinson invents a new way to communicate: e-mailComputer
1972Scientist realise that the DNA composition of chimpanzees is 99% identical to that of ManDiscovery
1973The Protein Data Bank containing all known information about protein structures is createdComputer
1974The idea arises to link several computers through an internetComputer
1976Building of the first supercomputer: it could perform 160 million operations per second and had a memory of 8 MBComputer
1981A machine is built to bind nucleotides together and thus build small pieces of genesExperimental
1981IBM introduces its Personal Computer: a computer for everyoneComputer
1983A new technique is developed to make exact copies of DNA in large amounts: PCRExperimental
1983The Compact Disc is brought to the marketComputer
1986The term genomics is used for the first time and describes the science of sequencing, mapping and analyzing genes--
1986The Swiss-Prot databank is started, containing all known information about proteinsComputer
1988The Human Genome Project is launched--
1991The European research center CERN develops the World Wide WebComputer
1994The first breast cancer gene is discoveredDiscovery
1995For the first time, the complete genome of a bacterium is sequencedDiscovery
1997The sheep Dolly is cloned in ScotlandExp./Disc.
1998The first complete animal genome is sequenced: a wormDiscovery
2001The human genome is published, although a few gaps remainDiscovery
2005The monkey genome is publishedDiscovery